2-((3-(4-Hydroxy-2,5-diMethoxyphenyl)acryloyl)oxy)-N,N,N-triMethylethanaMiniuM thiocyanate
Sinapinethiocyanate
CAS: 7431-77-8
Molecular Formula: C16H24NO5.CNS
2-((3-(4-Hydroxy-2,5-diMethoxyphenyl)acryloyl)oxy)-N,N,N-triMethylethanaMiniuM thiocyanate - Names and Identifiers
2-((3-(4-Hydroxy-2,5-diMethoxyphenyl)acryloyl)oxy)-N,N,N-triMethylethanaMiniuM thiocyanate - Physico-chemical Properties
| Molecular Formula | C16H24NO5.CNS |
| Molar Mass | 368.452 |
| Melting Point | 177-182oC |
| Solubility | Soluble in methanol |
| Appearance | White powder or crystal |
| Color | White to Off-White |
| Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| Stability | Hygroscopic |
| MDL | MFCD13195301 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from rape seeds, semen raphani, white mustard seed. |
| In vitro study | Sinapine (6 or 60 μM; 1 h) counteracts H 2 O 2 and antimycin A-induced mitochondrial oxidative stress in cardiomyocytes. Sinapine (10-200 μM; 24 h) inhibits the proliferation of Caco-2 cells in a dose-dependent manner, and has relatively low toxicity. Sinapine (10-200 μM; 24 h) promotes doxorubicin accumulation in Caco-2 cell by inducing P-glycoprotein (P-gp) decrease. Sinapine (10-200 μM; 24 h) significantly reduces phosphorylation of FRS2α, ERK1/2. |
| In vivo study | Sinapine reduces non-alcoholic fatty liver disease in mice by modulating the composition of the gut microbiota. |
2-((3-(4-Hydroxy-2,5-diMethoxyphenyl)acryloyl)oxy)-N,N,N-triMethylethanaMiniuM thiocyanate - Reference
| Reference Show more | 1. Tian Yuan, Fan Hui, Yu Yan, et al. Optimization of ethanol extraction process of vojiu plaster by multi-index comprehensive scoring method [J]. Journal of Liaoning University of Traditional Chinese Medicine, 2020, 26 (1):15-17. |
2-((3-(4-Hydroxy-2,5-diMethoxyphenyl)acryloyl)oxy)-N,N,N-triMethylethanaMiniuM thiocyanate - Reference Information
| treatment of Alzheimer's disease | inhibition of sinapine thiocyanate on acetylcholinesterase, calcium channel function, NO inhibition, it is found that sinapine thiocyanate can inhibit Acetylcholinesterase (AChE) in vitro and in vivo, that is, sinapine thiocyanate can inhibit the hydrolysis of acetylcholine by inhibiting AChE, the accumulation of acetylcholine in the body exhibits a choline receptor agonist-like effect. Because in many kinds of drugs for the prevention and treatment of AD, AChE inhibitors are one of the most effective drugs for the treatment of AD. Hypertension is the first of the three major risk factors of AD. If sinapine thiocyanate can simultaneously reduce blood pressure and treat AD, it will become a new generation of AD treatment drugs. Cruciferous plant fruit rapeseed meal contains a large amount of sinapine thiocyanate components, sinapine thiocyanate with antihypertensive, asthma, diastolic smooth muscle, inhibition of cholinesterase activity, the study found that sinapine thiocyanate inhibition of acetylcholinesterase activity, antagonism of calcium ion and inhibition of nitric oxide can improve the cognitive function of Alzheimer's disease model mice, increase the concentration of sinapine thiocyanate, enhance the inhibition of acetylcholinesterase, the half inhibitory concentration is 24.86mg/ml, sinapine thiocyanate is a calcium antagonist at low dose, and sinapine Thiocyanate inhibits nitric oxide significantly at low dose. Sinapine thiocyanate can play a role in treating AD in combination with three pathways. |
| biological activity | Sinapine thioate is an alkaloid isolated from the seeds of cruciferous species. Sinapine thiocyanate has anti-inflammatory, antioxidant, anti-tumor, anti-angiogenic and radioprotective effects. Sinapine thiocyanate is also an acetylcholinesterase (AChE) inhibitor used in the study of Alzheimer's disease, ataxia, myasthenia gravis and Parkinson's disease. |
| Target | AChE, P-gp |
| Use | sinapine thiocyanate has the effects of lowering blood pressure, scavenging free radicals, anti-oxidation, lowering cholesterol and preventing thrombosis. for content determination/identification/pharmacological experiments. Pharmacological Efficacy: antihypertensive effect |
Last Update：2024-04-09 21:21:28
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Product Name: Sinapine thiocyanate Visit Supplier Webpage Request for quotationCAS: 7431-77-8
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Product Name: Sinapine thiocyanate Visit Supplier Webpage Request for quotationCAS: 7431-77-8
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Tel: +86-18821248368
Email: Int06@meryer.com
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View History
2-((3-(4-Hydroxy-2,5-diMethoxyphenyl)acryloyl)oxy)-N,N,N-triMethylethanaMiniuM thiocyanate
N-(([(4-CHLOROBENZYL)OXY]IMINO)METHYL)-1-(2-PYRIMIDINYL)-4-PIPERIDINECARBOXAMIDE
(4-BENZYLPIPERAZIN-1-YL)(2-(ISOPENTYLAMINO)PYRIDIN-3-YL)METHANONE
4-AMino-1,3-diMethyl-1H-p...
2-(叔丁基二甲基硅基氧)乙醇
1-Chloro-2-piperidinoethane hydrochloride
3-HYDROXYDECANOIC ACID
261760-23-0
Carbamic acid, [(2S)-2-(methylamino)propyl]-, 1,1-dimethylethyl ester (9CI)
5-硝基-2-溴吡啶
N-(([(4-CHLOROBENZYL)OXY]IMINO)METHYL)-1-(2-PYRIMIDINYL)-4-PIPERIDINECARBOXAMIDE
(4-BENZYLPIPERAZIN-1-YL)(2-(ISOPENTYLAMINO)PYRIDIN-3-YL)METHANONE
4-AMino-1,3-diMethyl-1H-p...
2-(叔丁基二甲基硅基氧)乙醇
1-Chloro-2-piperidinoethane hydrochloride
3-HYDROXYDECANOIC ACID
261760-23-0
Carbamic acid, [(2S)-2-(methylamino)propyl]-, 1,1-dimethylethyl ester (9CI)
5-硝基-2-溴吡啶